Cureus

Muscle and Bone Side Effects Linked to Semaglutide, Liraglutide, and Tirzepatide in FDA Reports

GLP-1 Therapies Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are commonly prescribed for type 2 diabetes and obesity.

  • The musculoskeletal effects of GLP-1 RAs are not fully understood.
  • There is concern regarding lean-mass loss associated with GLP-1 RA treatment.
  • Lean-mass loss may indicate potential muscle atrophy and related complications.

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