Altered myocardial metabolic adaptation to increased fatty acid availability in cardiomyocyte-specific CLOCK mutant mice

Chronic increases in fatty acid availability may influence cardiac function differently in wild-type and cardiomyocyte-specific CLOCK mutant mice.

• Fatty acid availability is linked to cellular and organ dysfunction in cardiometabolic diseases such as obesity and diabetes.
• The heart can adapt to elevated fatty acid levels through various biological processes to reduce the risk of cardiomyopathy.
• The cardiomyocyte circadian clock may regulate the heart's ability to respond to sustained fatty acid availability.
• Increases in fatty acid availability were tested in both diabetic and high-fat diet conditions over a period of 9 weeks.
• Metabolic adaptations in the heart, including changes in substrate reliance, varied based on the genetic background of the mice.
• The induction of certain mRNA in the heart during diabetes was reduced in CLOCK mutant mice compared to wild-type mice.

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