Full text is available at the source.
The Circadian Clock within the Cardiomyocyte Is Essential for Responsiveness of the Heart to Fatty Acids
The heart's internal daily clock is essential for its response to fatty acids
AI simplified
Abstract
Reversal of the 12-h light/dark cycle in rats requires 5-8 days for complete re-entrainment of the circadian clock within the heart.
- The circadian clock in heart cells helps the organ adapt rapidly to fatty acid availability.
- Diurnal variations in how heart cells respond to fatty acids persist in isolated adult rat cardiomyocytes.
- Fasting induces genes that respond to fatty acids in the heart, but this effect is significantly reduced 2 days after altering the light/dark cycle.
- Disruption of the circadian clock in heart cells through a specific genetic change leads to a severe reduction in the activation of fatty acid-responsive genes during fasting.
- These findings suggest a connection between the circadian rhythm in heart cells and the metabolism of fatty acids.
AI simplified