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The circadian clock within the heart: potential influence on myocardial gene expression, metabolism, and function
The heart’s internal clock and its possible effects on heart gene activity, metabolism, and function
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Abstract
Diurnal variations in the responsiveness of the cardiovascular system may be influenced by both extracellular and intracellular factors.
- Intrinsic properties of the heart and blood vessels show significant changes throughout the day.
- The cardiovascular system's response to environmental changes is regulated by neurohumoral and circadian influences.
- The intracellular circadian clock helps cells recognize the time of day, preparing them for expected stimuli.
- Recent studies suggest that the circadian clock in the heart may influence myocardial metabolism.
- This metabolic modulation could assist in adapting to daily fluctuations in workload and energy supply.
- Potential links between circadian clock dysfunction and cardiovascular diseases like hypertension and diabetes are explored.
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