Cardiovascular research

Daily changes in heart muscle metabolism

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

The heart's metabolism may vary significantly throughout the day due to its intrinsic circadian clock.

  • Myocardial contractile function is influenced by various external stimuli over the course of a day.
  • Diurnal variations in heart metabolism are linked to the heart's intrinsic properties and responsiveness.
  • The intramyocardial circadian clock regulates metabolism directly by affecting triglyceride and glycogen processing.
  • The clock also influences the heart's response to workload, insulin, and fatty acids indirectly.
  • Regular feeding schedules may enhance the synchronization between the heart's metabolism and environmental stimuli.
  • Disruption of the circadian clock could lead to metabolic maladaptation and impaired heart function.

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