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Myomerger-derived peptide enhances skeletal muscle tropism and reduces liver transduction of lipid nanoparticles for gene delivery
Peptide from Myomerger improves muscle targeting and lowers liver delivery of lipid nanoparticles for gene therapy
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Abstract
MyomP1-LNPs significantly enhanced muscle transduction efficiency while reducing liver accumulation and local immune activation.
- Lipid nanoparticles (LNPs) can be modified to improve delivery to specific tissues, such as skeletal muscle.
- Functionalization with MyomP1, a peptide from a muscle-specific protein, was associated with enhanced gene delivery to muscle cells.
- MyomP1-LNPs demonstrated a notable increase in transduction efficiency in both murine and human muscle cells.
- The modified LNPs reduced liver accumulation when delivering mRNA and DNA, indicating improved tissue specificity.
- There was a reduction in local immune activation observed with MyomP1-LNPs compared to traditional delivery methods.
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