Characterization of topology-, gestation- and labor-related changes of a cassette of myometrial contraction-associated protein mRNA in the pregnant baboon myometrium

Dec 12, 2001The Journal of endocrinology

Changes in key muscle contraction gene activity in different areas of the pregnant baboon uterus during pregnancy and labor

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Abstract

TSP1 mRNA increased significantly in both the fundus and lower uterine segment during labor.

  • ER alpha and progesterone receptor mRNA levels did not change in the lower uterine segment or fundus during late gestation or spontaneous labor.
  • Oxytocin receptor mRNA remained the same in the lower uterine segment and fundus for baboons not in labor but showed an increase with gestation in non-labor fundal myometrium.
  • During spontaneous labor, fundal oxytocin receptor mRNA rose significantly compared to the lower uterine segment.
  • TSP1 mRNA levels in the lower uterine segment were higher than in the fundus during spontaneous labor.
  • The increase in oxytocin receptor mRNA may enhance uterine sensitivity to oxytocin during late gestation.

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