Assorted Applications of N-substituted-2,4-thiazolidinediones in Various Pathological Conditions

Thiazolidine-2,4-dione (TZD) has been implicated in the design of compounds for various pathogenic conditions, including cancer.

• Substitutions at the 5th position of TZD have led to the development of glitazones, which target peroxisome proliferating activated receptor γ (PPARγ).
• The acidic hydrogen (-NH) of TZD is essential for activating PPARγ.
• Advanced in-silico techniques have enabled the design of TZD derivatives targeting enzymes involved in diabetes, hyperlipidemia, infectious diseases, inflammation, and cancer.
• Methylene and N-substituted TZDs have shown promising activities in multiple therapeutic areas.
• The information compiled may assist researchers in modifying existing ligands and designing new TZD derivatives with improved safety and efficacy.

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