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Abstract
The phage protein AcrVA2 triggers translation-coupled mRNA degradation by recognizing nascent Cas12.
- An unusual anti-CRISPR mechanism was identified involving the interaction between AcrVA2 and Cas12.
- The recognition of nascent Cas12 by AcrVA2 leads to the degradation of mRNA during translation.
- These findings imply that nascent peptides could play a significant role in gene regulation.
- The mechanism may reflect an ongoing evolutionary conflict between mobile genetic elements and their hosts.
Simplified
CRISPR Gene Editing