Neonatal overnutrition in mice exacerbates high-fat diet-induced metabolic perturbations

CPO mice exhibited accelerated body weight gain and increased body fat mass prior to weaning, with differences persisting into adulthood.

• Chronic postnatal overnutrition (CPO) in mice is associated with accelerated development of metabolic defects when exposed to a high-fat diet (HFD) in adulthood.
• Insulin signaling is more severely impaired in the fat tissue of CPO mice fed an HFD compared to control mice.
• CPO mice show exaggerated increases in pro-inflammatory cytokines and greater macrophage infiltration in response to HFD.
• CPO mice have reduced levels of several enzymes involved in fat production and exhibit excess fat accumulation within muscle cells.

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