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Nesfatin-1 modulates murine gastric vagal afferent mechanosensitivity in a nutritional state dependent manner
Nesfatin-1 changes stomach nerve sensitivity in mice depending on their nutritional state
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Abstract
Nesfatin-1 modulates gastric vagal afferent mechanosensitivity in a nutritional state-dependent manner.
- High fat diet (HFD) mice showed increased body weight and fat accumulation.
- Plasma levels of nesfatin-1 precursor (NUCB2) remained unchanged across different dietary groups.
- NUCB2 mRNA was present in the gastric lining and fat tissue of all dietary conditions without significant differences.
- In standard laboratory diet (SLD) and fasted mice, nesfatin-1 enhanced mechanosensitivity of mucosal receptors.
- Nesfatin-1 did not affect tension receptor mechanosensitivity in SLD and fasted mice but inhibited it in HFD mice.
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