Unraveling the complexity of neurodegeneration in brains of subjects with Down syndrome: Insights from proteomics

After age 40, most individuals with Down syndrome develop dementia resembling Alzheimer's disease.

• Down syndrome is associated with neurodegeneration characterized by complex neuropathology.
• Impaired mitochondrial function, increased oxidative stress, and altered protein management may contribute to neurodegeneration in Down syndrome.
• Increased oxidative damage and accumulation of misfolded protein aggregates are critical to neurodegenerative processes.
• Chronic oxidative stress in Down syndrome may accelerate cognitive and memory decline.
• Changes in redox status in Down syndrome neurons could create conditions that promote neurodegeneration as individuals age.

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