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Abstract
Recent findings indicate that immune abnormalities may contribute to the pathogenesis of Alzheimer's disease.
- Intracerebral accumulation of amyloid beta and tau aggregates is associated with the development of Alzheimer's disease.
- Numerous experimental and clinical studies targeting amyloid beta and tau proteins have not achieved significant clinical success.
- Several immune and microglia-related genes have been identified as potential causative factors for Alzheimer's disease.
- Dysfunction of microglia and the immune system in the central nervous system could lead to chronic neuroinflammation.
- Neuroimmune dysfunction is linked to the pathogenesis of Alzheimer's disease and other forms of dementia.
- Future therapeutic approaches may involve targeting specific signals and immune cell populations relevant to Alzheimer's disease.
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