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Longitudinal evaluation of neurologic-post acute sequelae SARS-CoV-2 infection symptoms.
Long-term changes in brain-related symptoms after COVID-19 infection
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Abstract
Fifty-six participants with neurologic symptoms following SARS-CoV-2 infection were assessed, with 33.3% reporting complete symptom resolution by 6 months.
- The most common neurologic symptoms reported at baseline were fatigue (89.3%) and headaches (80.4%).
- Memory impairment (68.8%) and decreased concentration (61.5%) were the most prevalent symptoms at the 6-month follow-up.
- Average scores on the Montreal cognitive assessment improved overall, though 26.3% of participants experienced a decrease in scores.
- A syndrome characterized by tremor, ataxia, and cognitive dysfunction was observed in 7.1% of participants.
- Participants generally reported a reduction in the severity of all symptoms from baseline to 6 months.
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Key numbers
66.7%
Persistent Neurologic Symptoms
Percentage of participants reporting persistent symptoms at 6 months.
68.8%
Memory Impairment
Percentage of participants reporting memory impairment at 6 months.
−19.2%
Decrease in Fatigue Severity
Average percentage decrease in fatigue severity scores from baseline to 6 months.