Neurological outcome after minimal invasive coronary artery surgery (NOMICS): protocol for an observational prospective cohort study

Oct 9, 2017BMJ open

Brain function after minimally invasive heart artery surgery: plan for a forward-looking study

AI simplified

Circadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

A prospective observational cohort study will include 150 patients to examine neurocognitive outcomes after Endoscopic Coronary Artery Bypass Grafting (Endo-CABG).

The study categorizes patients into three groups: those undergoing Endo-CABG, those receiving a percutaneous coronary intervention, and healthy volunteers.
Neurocognitive outcomes will be assessed using a battery of six tests at baseline and three months post-surgery.
Primary endpoints include the incidence of postoperative cognitive dysfunction (POCD), stroke, and delirium after Endo-CABG.
Secondary endpoints involve evaluating quality of life, anxiety, and depression levels at three months following surgery.
Patient satisfaction with the Endo-CABG procedure will also be assessed at the three-month follow-up.

AI simplified

INTRODUCTION: Adverse neurocognitive outcomes are still an important cause of morbidity and mortality after cardiac surgery. The most common neurocognitive disorders after conventional cardiac surgery are postoperative cognitive dysfunction (POCD), stroke and delirium. Minimal invasive cardiac procedures have recently been introduced into practice. Endoscopic coronary artery bypass grafting (Endo-CABG) is a minimal invasive cardiac procedure based on the conventional CABG procedure. Neurocognitive outcome after minimal invasive cardiac surgery, including Endo-CABG, has never been studied. Therefore, the main objective of this study is to examine neurocognitive outcome after Endo-CABG.

METHODS AND ANALYSIS: We will perform a prospective observational cohort study including 150 patients. Patients are categorised into three groups: (1) patients undergoing Endo-CABG, (2) patients undergoing a percutaneous coronary intervention and (3) a healthy volunteer group. All patients in the Endo-CABG group will be treated following a uniform, standardised protocol. To assess neurocognitive outcome after surgery, a battery of six neurocognitive tests will be administered at baseline and at 3-month follow-up. In the Endo-CABG group, a neurological examination will be performed at baseline and postoperatively and delirium will be scored at the intensive care unit. Quality of life (QOL), anxiety and depression will be assessed at baseline and at 3-month follow-up. Satisfaction with Endo-CABG will be assessed at 3-month follow-up. Primary endpoints are the incidence of POCD, stroke and delirium after Endo-CABG. Secondary endpoints are QOL after Endo-CABG, patient satisfaction with Endo-CABG and the incidence of anxiety and depression after Endo-CABG.

ETHICS AND DISSEMINATION: The neurological outcome after minimal invasive coronary artery surgery study has received approval of the Jessa Hospital ethics board. It is estimated that the trial will be executed from December 2016 to January 2018, including enrolment and follow-up. Analysis of data, followed by publication of the results, is expected in 2018.

TRIAL REGISTRATION NUMBER: NCT02979782.

Full Text

We can’t show the full text here under this license. Use the link below to read it at the source.

View full text ↗

Neurological outcome after minimal invasive coronary artery surgery (NOMICS): protocol for an observational prospective cohort study

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief

Abstract

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief