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Abstract
Neuronal activity regulates a core set of brain endothelial genes associated with blood-brain barrier properties.
- Neuronal activity influences the expression and function of BBB efflux transporters, which play a key role in preventing the entry of certain small lipophilic molecules into the brain.
- Circadian clock genes in brain endothelial cells are regulated by neuronal activity, affecting the control of BBB efflux transport.
- These findings suggest a potential link between neuronal activity and the clearance of waste products from the central nervous system, including amyloid-beta (Aβ).
- The regulation of BBB properties by neuronal activity may have clinical implications for drug delivery to the CNS.
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