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Abstract
Circadian rhythms may significantly influence the passage of substances through the blood-brain barrier (BBB).
- The blood-brain barrier separates the central nervous system from peripheral circulation, maintaining brain function.
- Circadian rhythms synchronize biological processes with the 24-hour light-dark cycle and may affect BBB functions.
- Efflux transporters, which help regulate substance movement across the BBB, are influenced by molecular timing mechanisms.
- Understanding temporal changes in the BBB could optimize the timing of drug administration for neurological disorders.
- Chronotherapy may enhance the effectiveness of drug delivery to the brain while minimizing side effects.
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