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Circadian rhythms: influence on physiology, pharmacology, and therapeutic interventions
How Body Clocks Affect Body Functions, Drug Responses, and Treatments
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Abstract
Circadian rhythms orchestrate a wide range of molecular, physiological, and behavioral processes.
- Circadian clocks consist of a hierarchical network of central and peripheral clocks that synchronize daily rhythms.
- Peripheral clock functioning is influenced by signals from the central clock, hormones, feeding, and external cues.
- Disruption of circadian rhythms is associated with negative impacts on human health and can lead to various disorders.
- Pharmacokinetics and pharmacodynamics are subject to circadian oscillations, affecting the efficacy and toxicity of therapeutic agents.
- Modeling approaches have been utilized to explore circadian biology, optimize drug dosing times, and understand pharmacological effects on clock mechanisms.
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