Dosing-Time Makes the Poison: Circadian Regulation and Pharmacotherapy

Daily rhythms in physiology significantly influence drug effects and metabolism.

• Drug pharmacokinetics and pharmacodynamics vary based on the time of day.
• The molecular circadian clock has a crucial role in the metabolism of foreign substances.
• Mechanistic insights into the circadian timing system can enhance understanding of drug variations and environmental substance effects.
• Current research focuses on how the biological clock impacts drug efficacy and side effects.
• New molecular strategies are being explored to address disruptions in the circadian clock related to diseases and medications.

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