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Mathematical modeling of mammalian circadian clocks affecting drug and disease responses
Mathematical modeling of daily body clocks influencing drug reactions and disease responses in mammals
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Abstract
Circadian control affects numerous molecular and cellular processes in mammals.
- Most physiological processes in mammals show rhythmicity aligned with daily environmental changes.
- A cell-autonomous clock gene network drives the rhythmic expression of genes across nearly all body cells.
- Pharmacology and toxicology also exhibit time-of-day variations, influencing drug effects on the body.
- Genome-wide studies and mathematical modeling have enhanced understanding of these nonlinear physiological aspects.
- Integrative approaches may lead to new strategies for chronotherapeutic treatments and insights into circadian system restoration.
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