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Neuropsin (OPN5) Mediates Local Light-Dependent Induction of Circadian Clock Genes and Circadian Photoentrainment in Exposed Murine Skin
Light-sensitive Neuropsin controls daily clock genes and light-based timing in mouse skin
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Abstract
Light exposure can phase shift skin circadian rhythms, which requires Opn5 gene function.
- Nearly all mammalian tissues possess autonomous circadian clocks that need synchronization to a 24-hour day.
- Melanocyte precursor cells in hair and vibrissal follicles express a photopigment called neuropsin (OPN5).
- Organotypic cultures of murine skin can entrain to light-dark cycles, relying on a specific chromophore and the Opn5 gene.
- Short-wavelength light can significantly alter skin clock rhythms in a manner dependent on Opn5.
- In specific mice unable to behaviorally synchronize to light-dark cycles, skin clock gene expression remains aligned with the light-dark cycle, while other clocks do not.
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