Annual review of vision science

How Eye Light Detection Helps Mammals Set Their Body Clocks

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Mice lacking all rod and cone photoreceptors still exhibit photic entrainment mediated by intrinsically photosensitive retinal ganglion cells (ipRGCs).

  • Intrinsically photosensitive retinal ganglion cells (ipRGCs) utilize melanopsin for light detection.
  • Melanopsin functions differently from other photopigments, exhibiting stable photocycle properties.
  • The retina can act as a circadian pacemaker, independently entrained by light-dark cycles.
  • A novel opsin, neuropsin, is essential for the light entrainment of the retina and involves a distinct population of ipRGCs.
  • The mammalian cornea also displays light entrainability through a neuropsin-dependent mechanism.

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