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Abstract
Diabetes mellitus is the leading cause of chronic kidney disease and kidney failure worldwide.
- Diabetic kidney disease (DKD) is linked to higher rates of cardiovascular and overall mortality.
- The progression of DKD involves complex interactions of blood flow, metabolism, and inflammation.
- Current management focuses on four main types of medications that target the renin-angiotensin-aldosterone system and glucose regulation.
- Despite optimal treatment, significant risk for heart and kidney complications remains in patients with DKD.
- New therapies under development aim to enhance current treatments and improve health outcomes for patients with DKD.
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