A Review on the Development in the Field of NIDDM based Thiazolidinedione PPARγ Agonists

Apr 20, 2012Mini reviews in medicinal chemistry

Advances in diabetes drugs targeting PPAR gamma with thiazolidinediones

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Abstract

This article reviews reported thiazolidinediones and their interactions with PPARγ.

PPARγ are transcription factors involved in regulating metabolic processes.
Thiazolidinediones are small molecules that activate PPARγ.
The article examines functional and structural features of thiazolidinedione binding to PPARs.
A comprehensive overview of PPARγ ligands is provided.
Understanding these interactions may contribute to insights in metabolic regulation.

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Peroxisome Proliferator Activated Receptors gamma (PPARγ) are a class of ligand activated transcription factors with a prominent role in the regulation of metabolic processes. The present work aims towards examining the functional and structural features that facilitate the binding of small molecules based on Thiazolidinedione pharmacophore to PPARs. The intent of this article is to review all the reported thiazolidinediones and associated groups of PPARγ ligands.

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A Review on the Development in the Field of NIDDM based Thiazolidinedione PPARγ Agonists

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