Night shift work and indicators of cardiovascular risk: A systematic review and meta-analysis

Of the 8,387 studies identified, 81 were included, indicating a significant association between night shift work and cardiovascular risk indicators.

• Moderate-confidence evidence shows increased inflammation, dyslipidaemia, and impaired cardiac excitability in night shift workers.
• A dose-dependent relationship suggests that the intensity and duration of night shift work may contribute to cardiovascular disease risk.
• No association was found between night shift work and indicators of vascular dysfunction or alterations in the autonomic nervous system.
• Regulatory and preventative initiatives could be important to mitigate cardiovascular risks for night shift workers.

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