Night shift work and chronic lymphocytic leukemia in the MCC‐Spain case–control study

Jul 15, 2016International journal of cancer

Night shift work and risk of chronic lymphocytic leukemia in a Spain-based study

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Abstract

Long-term night shift work (>20 years) is positively associated with chronic lymphocytic leukemia (CLL) with an odds ratio of 1.77.

Working night shifts overall is not associated with CLL (OR = 1.06; 95% CI = 0.78-1.45).
Among those with rotating night shifts, a positive association with CLL was observed (OR = 2.29; 95% CI = 1.33-3.92).
No significant association was found for permanent night shifts (OR = 1.16; 95% CI = 0.60-2.25).
No linear trend in risk was observed for duration of night shift work (P trend = 0.18).
The findings suggest that further investigation into the association between CLL and long-term rotating night shift work is warranted.

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Chronic lymphocytic leukemia (CLL) has few known modifiable risk factors. Recently, circadian disruption has been proposed as a potential contributor to lymphoid neoplasms' etiology. Serum melatonin levels have been found to be significantly lower in CLL subjects compared with healthy controls, and also, CLL prognosis has been related to alterations in the circadian molecular signaling. We performed the first investigation of an association between night shift work and CLL in 321 incident CLL cases and 1728 population-based controls in five areas of Spain. Participants were interviewed face-to-face by trained interviewers to collect information on sociodemographic factors, familial, medical and occupational history, including work shifts and other lifestyle factors. We used logistic regression models adjusted for potential confounders to estimate odds ratios (OR) and 95% confidence intervals (CI). Seventy-nine cases (25%) and 339 controls (20%) had performed night work. Overall, working in night shifts was not associated with CLL (OR = 1.06; 95% CI = 0.78-1.45, compared with day work). However, long-term night shift (>20 years) was positively associated with CLL (OR(tertile 3 vs . day-work) = 1.77; 95% = 1.14-2.74), although no linear trend was observed (P trend = 0.18). This association was observed among those with rotating (OR(tertile 3 vs . day-work) = 2.29; 95% CI = 1.33-3.92; P trend = 0.07), but not permanent night shifts (OR(tertile 3 vs . day-work) = 1.16; 95% CI = 0.60-2.25; P trend = 0.86). The association between CLL and long-term rotating night shift warrants further investigation.

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Night shift work and chronic lymphocytic leukemia in the MCC‐Spain case–control study

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