Full text is available at the source.
Nocturnal light exposure aggravates schizophrenia via gut microbiota mediated lipid metabolism: Human and animal multi-omics evidence
Nighttime light worsens schizophrenia by changing gut bacteria and fat metabolism: evidence from humans and animals
AI simplified
Abstract
Reduced artificial light at night (ALAN) exposure was associated with lower depression and psychosis scores in schizophrenia patients.
- Lower Early Signs Scale (ESS) scores for depression and incipient psychosis were observed with reduced ALAN.
- Higher Montreal Cognitive Assessment (MoCA) scores were associated with reduced ALAN exposure.
- Stabilized gut microbiota and improved linoleic acid metabolism were linked to the benefits of reduced ALAN.
- In a mouse model, ALAN exposure led to gut dysbiosis, disrupted linoleic acid metabolism, and behaviors resembling schizophrenia.
- Linoleic acid supplementation partially improved behavioral outcomes in mice exposed to ALAN.
AI simplified