We can’t show the full text here under this license.
Links between outdoor artificial light at night, body clock health, and 'bad' cholesterol in brain artery narrowing
Updated
Abstract
A total of 1010 patients were evaluated, with 32 classified as having poor control after three months.
- Outdoor artificial light at night () exposure is associated with poorer control of low-density lipoprotein cholesterol (LDL-C) in patients with intracranial artery atherosclerotic stenosis (ICAS).
- For each increase of 1 nW/cm²/sr in ALAN intensity, the odds of poor LDL-C control increased by 2%.
- Metabolic profiling suggests that ALAN may influence lipid metabolism through its effects on specific proteins involved in lipid transport.
- Dim ALAN exposure in animal studies led to global hypomethylation, while melatonin treatment appeared to mitigate some of these effects.
- The findings imply that disruptions in circadian rhythms and changes in DNA methylation may play a role in the relationship between ALAN exposure and LDL-C control.
Simplified
Key numbers
1.02
Increase in Odds of Poor Control
Odds ratio for control status per 1 nW/cm/sr increase in exposure
86%
Global Methylation Reduction
Percentage decrease in global methylation levels in dLAN-exposed mice compared to controls
1010
Patient Cohort Size
Total number of patients included in the study