Molecular processes involved in the development and worsening of nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum of liver conditions, from simple fat accumulation to severe liver damage.

• NAFLD is associated with metabolic syndrome and can progress to more severe forms like nonalcoholic steatohepatitis (NASH) and cirrhosis.
• The initial development of NAFLD may be triggered by the accumulation of toxic free fatty acids due to insulin resistance.
• Progression of the disease involves multiple injury mechanisms, including oxidative stress and inflammation.
• Key features of NASH include inflammation, cell death, and fibrosis, which are linked to various stressors and signaling pathways.
• Understanding molecular mechanisms is crucial for identifying factors that influence the onset and progression of NAFLD.

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