Non-statin treatments for managing unhealthy blood fat levels

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the United States.

• Cholesterol treatment guidelines prioritize statins for preventing CVD.
• The effectiveness of combination therapy for patients intolerant to statins remains uncertain.
• Recent evidence shows no significant improvement in cardiovascular outcomes with combination therapy.
• This review evaluates nonstatin drug classes aimed at reducing cardiovascular outcomes.
• Recommendations for the use of nonstatin therapies in clinical practice are provided.

Simplified