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Noradrenergic modulation of central serotonergic neurotransmission: acute and long-term actions of mirtazapine
How noradrenaline affects serotonin signaling in the brain during short- and long-term mirtazapine treatment
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Abstract
Mirtazapine administration caused a rapid increase in both noradrenaline and serotonin neurotransmission.
- Acute treatment with mirtazapine blocked alpha2-adrenergic receptors, leading to increased neurotransmission of noradrenaline and serotonin.
- This increase resulted in enhanced activation of serotonin receptors on the receiving neurons.
- Long-term treatment likely sustained this increase in serotonin activity by keeping certain receptors inactivated.
- The overall effect suggests that mirtazapine may modulate serotonin neurotransmission through its action on alpha2-adrenergic receptors.
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