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Advances in modification and delivery of nucleic acid drugs
New ways to improve and deliver gene-based drugs
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Abstract
Nucleic acid-based drugs, such as RNA and DNA drugs, often face challenges like poor stability and weak targeting specificity.
- Chemical modifications of nucleic acid structures may enhance stability and targeting specificity.
- Nucleic acid drug carriers can facilitate transportation to lesion sites, aiding intracellular escape.
- Commonly used delivery carriers include virus vectors, lipid nanoparticles, and extracellular vesicles.
- Individual modifications or delivery carriers alone may not overcome all obstacles in drug delivery.
- Integrating nucleic acid modifications with delivery systems could improve therapeutic effects but increases technical complexity.
- Research is focusing on developing practical modifications and carriers that ensure high efficacy and low toxicity.
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