Frontiers in neuroanatomy

How GLP-1 signals in the brain's reward center may influence reward and metabolism

Updated

Abstract

Glucagon-like peptide-1 (GLP-1) is involved in metabolic and reward processes in the human nucleus accumbens.

  • GLP-1 plays a role in regulating glucose levels, appetite, and energy balance.
  • Evidence suggests that GLP-1 signalling in the brain may influence reward-related behaviors.
  • The nucleus accumbens is identified as a critical area where metabolic and motivational signals interact.
  • Current understanding of GLP-1 expression and receptor signalling in the human NAc is limited.

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