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Abstract
Recent studies indicate that microbial metabolites significantly impact GLP-1 secretion.
- Fermentation of dietary fibers produces short-chain fatty acids that stimulate GLP-1 secretion.
- Microbial metabolites such as indole derivatives, N-acyl glycines, and bile acid metabolites are involved in regulating hormone signaling.
- Dietary interventions like β-glucan supplementation and probiotics may influence GLP-1 secretion through mechanisms dependent on the gut microbiome.
- There is evidence supporting a relationship between nutrition, gut microbiome composition, and GLP-1 activity.
- Integrating microbiome profiling with dietary strategies could enhance metabolic therapies and clarify differences in responses to GLP-1 treatments.
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