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How Obesity and Diabetes Cause Inflammation and What It Means for Health
Updated
Abstract
Nutrient excess may trigger immune activation through pattern recognition receptors and the NLRP3 inflammasome, leading to interleukin (IL)-1β production.
- Chronic inflammation is linked to obesity and its related disorders, including type 2 diabetes and cardiovascular diseases.
- Initially adaptive inflammation can lead to beneficial tissue remodeling and metabolic compensation.
- Persistent inflammation is associated with insulin resistance, β cell dysfunction, and damage to organs.
- Glucagon-like peptide-1 (GLP-1) receptor agonists have demonstrated notable anti-inflammatory effects.
- Some effects of GLP-1 medicines may occur independently of glucose control or weight loss.
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