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Abstract
Nutrient excess may trigger immune activation through pattern recognition receptors and the NLRP3 inflammasome, leading to interleukin (IL)-1β production.
- Chronic inflammation is linked to obesity and its related disorders, including type 2 diabetes and cardiovascular diseases.
- Initially adaptive inflammation can lead to beneficial tissue remodeling and metabolic compensation.
- Persistent inflammation is associated with insulin resistance, β cell dysfunction, and damage to organs.
- Glucagon-like peptide-1 (GLP-1) receptor agonists have demonstrated notable anti-inflammatory effects.
- Some effects of GLP-1 medicines may occur independently of glucose control or weight loss.
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