Obesity and NAFLD

Nov 27, 2013Clinics in liver disease

How Gut Bacteria Are Linked to Obesity and Fatty Liver Disease

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Abstract

Obesity may be affected by gut microbiota through energy harvesting and fat storage by bacteria.

  • Trillions of microorganisms in the human intestine comprise the gut microbiota.
  • Small intestinal bacterial overgrowth is linked to endotoxemia and systemic inflammation.
  • Endotoxemia and inflammation are associated with obesity and nonalcoholic fatty liver disease (NAFLD).
  • The relationship between gut microbiota and NAFLD may depend on altered choline and bile acid metabolism.
  • Gut bacteria could contribute to the production of endogenous alcohol.
  • Probiotics have shown potential benefits in animals and patients with NAFLD.

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