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Abstract
Obstructive sleep apnea (OSA) may trigger physiological changes resembling cellular aging, including oxidative stress, mitochondrial dysfunction, and systemic inflammation.
- OSA is associated with repeated airway obstruction during sleep, leading to physiological changes linked to cellular aging.
- The accumulation of cellular senescence may drive chronic inflammation and immune system dysfunction in individuals with OSA.
- Key mechanisms such as the senescence-associated secretory phenotype (SASP) and impaired immune response could contribute to health issues in OSA patients.
- Senescence may influence immune and molecular pathways related to cardiometabolic dysfunction in the context of OSA.
- Emerging therapies targeting senescence could address OSA pathology, which is influenced by factors such as hypoxia and sleep disruption.
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