OGFOD1, a Novel Modulator of Eukaryotic Translation Initiation Factor 2α Phosphorylation and the Cellular Response to Stress

Overexpression of OGFOD1 leads to increased levels of phosphorylated eIF2alpha and accelerated apoptosis during stress.

• OGFOD1 is identified as a novel component of stress granules that regulates eIF2alpha phosphorylation.
• Coimmunoprecipitation studies show OGFOD1 interacts with specific stress granule proteins and the ribosome in both unstressed and stressed conditions.
• Knockdown of OGFOD1 results in reduced phosphorylated eIF2alpha and a quicker accumulation of polyribosomes during recovery from stress.
• Interactions between OGFOD1, eIF2alpha, and the eIF2alpha kinase heme-regulated inhibitor (HRI) suggest novel roles for HRI in stress granules.
• The findings indicate that OGFOD1 may have significant proapoptotic functions in the context of arsenite-induced stress.

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