Olive Oil Before Sugar Slows Stomach Emptying and Lowers Blood Sugar in Mice Through Glucagon and GLP-1 Signals

Olive oil consumption before glucose intake reduced early glycemia in mice.

• Olive oil increased levels of glucagon, glucose-dependent insulinotropic polypeptide, and glucagon-like peptide-1.
• The presence of olive oil slowed gastric emptying.
• Glucagon and glucagon-like peptide-1 signaling may work together to modulate glycemia.
• Vagal pathways are involved in the response to olive oil consumption.
• The findings suggest that nutrient timing could influence the regulation of gastric emptying and blood sugar levels.

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