ω‐3 PUFAs Alleviate High‐Fat Diet–Induced Circadian Intestinal Microbes Dysbiosis

Dietary supplements of fish oil and algae oil improve gut microbiota balance in mice on a high-fat diet.

• Mice fed a high-fat diet supplemented with fish oil or algae oil showed improvements in hyperlipidemia compared to those on the high-fat diet alone.
• Specific gut bacteria associated with short-chain fatty acid production, such as Butyricimonas, were restored to normal levels in the fish oil and algae oil groups.
• The relative abundance of certain bacterial genera was enhanced in the groups receiving fish oil and algae oil.
• Both fish oil and algae oil helped maintain the normal circadian rhythm of gut microbiota disrupted by the high-fat diet.

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