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OMICmAge quantifies biological age by integrating multi-omics with electronic medical records
Measuring Biological Age by Combining Multiple Molecular Data Types with Medical Records
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Abstract
EMRAge, a biomarker of mortality risk, was developed using clinical data from approximately 31,000 participants.
- EMRAge is associated with incident and prevalent chronic diseases and mortality.
- Two variants of EMRAge, DNAmEMRAge and OMICmAge, can be modeled using DNA methylation and multi-omics data.
- OMICmAge integrates multiple biological domains while remaining quantifiable from DNA methylation alone.
- Both DNAmEMRAge and OMICmAge perform comparably or better than current biomarkers in various cohorts.
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