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Changes in biological aging and DNA markers after ketamine treatment in patients with depression and PTSD
Updated
Abstract
Essence
This pilot study suggests six infusions may reduce several epigenetic aging measures in patients with MDD or PTSD while symptoms improve.
Evidence
A before-and-after pilot study of 20 participants with MDD or PTSD measured baseline and post-treatment DNA methylation, immune cell composition, and aging biomarkers and found decreases in PHQ-9 and PCL-5 scores alongside lower OMICmAge, GrimAge V2, and PhenoAge.
Caveat
The findings are preliminary because the sample was small and the abstract describes no control group, limiting causal inference about ketamine's effects on biological aging.
Simplified
Key numbers
33
Decrease in Score
Median difference in scores from baseline to post-treatment.
11
Decrease in Score
Median difference in scores from baseline to post-treatment.
0.038
Reduction in CD4T Memory Cells
Unadjusted p-value indicating significance of change post-treatment.
Psychedelic Science