Clinical rheumatology

Oral COVID-19 antivirals linked to risk of long COVID symptoms at 28 and 90 days in people with autoimmune rheumatic diseases

Updated

Abstract

Individuals with systemic autoimmune rheumatic diseases (SARDs) may experience lower risk of post-acute sequelae of COVID-19 (PASC) with antiviral use.

  • Antiviral medications have been studied for their potential impact on the risk of long COVID.
  • The focus has been on the general population in previous research.
  • This evaluation specifically targets individuals with systemic autoimmune rheumatic diseases.
  • The hypothesis suggests a possible link between antiviral use and reduced PASC risk.

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Funding

Competing interests

Compliance with ethical standards. Conflict of interest: Dr. Patel has received consulting fees from FVC Health, Arrivo Bio, Alosa Health, Guidepoint, and Mirador Therapeutics, and grant support from Amgen, unrelated to the current work. She also serves on the Independent Data Monitoring Committee for AstraZeneca/Everest Clinical Research. Dr. Sparks has received research support from Boehringer Ingelheim, Bristol Myers Squibb, Johnson & Johnson, and Sonoma Biotherapeutics unrelated to this work. He has performed consultancy for AbbVie, Amgen, Anaptys, Boehringer Ingelheim, Bristol Myers Squibb, Fresenius Kabi, Gilead, GSK, Inova Diagnostics, Invivyd, Johnson & Johnson, Merck, MustangBio, Novartis, Optum, Pfizer, ReCor, Sana, Sobi, and UCB unrelated to this work. The funders had no role in the decision to publish or preparation of this manuscript. The content is solely the responsibility of the authors and does not necessarily represent the official views of Harvard University, its affiliated academic health care centers, or the National Institutes of Health. All other authors have no conflicts of interest to report.
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