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Correlation between oral disease and neurodegenerative disorders: Role of biological proteins for the modulation of oral-brain axis and gut-brain axis
Links between oral health and brain diseases: How proteins affect communication between the mouth, gut, and brain
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Abstract
Biological proteins play a crucial role in linking oral health and neurodegenerative disorders.
- Oral diseases, particularly periodontal disease and microbial imbalances, are associated with neurodegenerative disorders such as Alzheimer's and Parkinson's disease.
- Key proteins involved in inflammation, neuroprotection, and tissue repair are vital for both oral health and neural function.
- Protein misfolding, aggregation, and immune responses may drive neuroinflammation and cognitive decline.
- Salivary proteomics and transcriptomics enable non-invasive detection of neurodegenerative biomarkers.
- Protein-based biomaterials, including hydrogels and nanocarriers, are emerging for delivering neuroprotective agents through oral and nasal routes.
- Advances in artificial intelligence, bioinformatics, and protein engineering could enhance personalized regenerative and preventive medicine.
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