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The benefit of adding oral simethicone in bowel preparation regimen for the detection of colon adenoma: A systematic review and meta‐analysis
Adding oral simethicone to bowel cleaning may improve detection of colon polyps
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Abstract
A total of 6003 participants were analyzed in twelve randomized controlled studies.
- There was no significant difference in overall adenoma detection rate (ADR) between groups with and without simethicone.
- The right-side ADR also showed no significant difference between the two groups.
- One study indicated that the addition of simethicone led to an increase in adenomas detected per patient (2.20 ± 1.36 vs 1.63 ± 0.89).
- Meta-regression analysis suggested that a baseline ADR of less than 25% was linked to a notable benefit from oral simethicone.
- The number needed to treat to observe a benefit in adenoma detection was 15.
- Oral simethicone improved bowel preparation quality in the analyzed studies.
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