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Ordered changes in histone modifications at the core of the Arabidopsis circadian clock
Step-by-step changes in gene packaging at the center of the Arabidopsis daily biological clock
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Abstract
Chromatin remodeling plays a critical role in the circadian clock function of Arabidopsis thaliana.
- The circadian oscillation is associated with the sequential accumulation of specific chemical modifications on histones, including H3 acetylation and H3K4 trimethylation.
- Inhibition of histone acetylation and H3K4 trimethylation disrupts the expression of clock-related genes.
- Blocking H3K4 trimethylation results in increased binding of clock repressors, indicating its role in the transition from gene activation to repression.
- Misexpression of the histone methyltransferase SET DOMAIN GROUP 2/ARABIDOPSIS TRITHORAX RELATED 3 alters oscillator gene expression and histone modifications.
- A chromatin-dependent mechanism of clock gene activation may be conserved across both plant and mammal circadian systems.
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