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Orexin: a Missing Link Between Sleep Disorders and Heart Failure?
Orexin’s possible role connecting sleep problems and heart failure
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Abstract
Treatment of sleep disorders, like obstructive sleep apnea, may significantly improve cardiac function in heart failure patients.
- Sleep disorders are a common comorbidity in individuals with heart failure.
- Recent findings suggest a novel neurohormonal pathway involving orexins that regulates autonomic function during sleep/wake cycles.
- Orexin signaling may be disrupted in sleep disorders, potentially contributing to heart failure pathology.
- Targeting the orexin signaling pathway could provide new therapeutic options for both sleep disorders and heart failure.
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