Oxytocin-induced cell growth proliferation in human myometrial cells and leiomyomas

Oxytocin stimulated proliferation of primary myometrial and leiomyoma cells.

• Oxytocin inhibited the proliferation of an immortalized myometrial cell line and a leiomyosarcoma cell line, suggesting a change in cell behavior due to immortalization.
• A rapid decrease in desmin and oxytocin receptor mRNA levels was observed in primary cultures, indicating that myometrial cells quickly lose their differentiated characteristics in culture.
• The expression levels of the oxytocin receptor mRNA varied significantly among both myometrial and leiomyoma smooth muscle cells, with no significant differences noted between the two cell types.

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