Oxytocin stimulates prostaglandin F2alpha secretion and prostaglandin F synthase protein expression in porcine myometrial tissue.

Oxytocin (10(-7) M) stimulated prostaglandin F(2)alpha production in both cycling and early pregnant myometrial slices.

• Prostaglandin F(2)alpha release was higher in early pregnant myometrial slices compared to cycling ones.
• Prostaglandin F synthase was present in both cyclic and early pregnant myometrial tissues.
• Oxytocin exposure resulted in stronger signals of prostaglandin F synthase in the cycling myometrium.
• No significant differences in prostaglandin F synthase expression were found between control and oxytocin-stimulated tissues in early pregnant sows.
• Oxytocin also increased protein expression of PGD(2) 11-ketoreductase in myometrial tissue during the estrous cycle.

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