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The P522R protective variant of PLCG2 promotes the expression of antigen presentation genes by human microglia in an Alzheimer's disease mouse model
Protective PLCG2 gene variant increases immune activation in brain support cells in an Alzheimer's mouse model
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Abstract
The -P522R variant is associated with increased microglial human leukocyte antigen expression and T cell recruitment in Alzheimer's disease models.
- The PLCG2-P522R variant may enhance microglial responses to Alzheimer's disease pathology.
- Increased expression of human leukocyte antigen () was observed in microglia carrying the PLCG2-P522R variant.
- The variant is linked to the activation of pathways related to antigen presentation, chemokine signaling, and T cell proliferation.
- Recruitment of CD8T cells to the brain was promoted in immune-intact Alzheimer's disease mice with the PLCG2-P522R variant.
- These findings suggest a transcriptional state in microglia that may be diminished in Alzheimer's disease patients.
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Key numbers
significant increase
Increase in CD8T Cells
CD8T cell count in -P522R KI 5XFAD mice vs. WT 5XFAD mice
significant increase
-DR Expression
-DR levels in P522R xMGs compared to WT xMGs